Nobivac Canine Lepto is a leptospirosis vaccine for dogs. This lepto 4 vaccine helps protect against disease, death and leptospiruria caused by Leptospira Canicola- Grippotyphosa-Icterohaemorrhagiae-Pomona. Helps to significantly reduce leptospiremia and aids in the prevention of leptospiruria, liver dysfunction and thrombocytopenia. Bacterin. Helps control disease, liver dysfunction, and death caused by Leptospira Aids in the prevention of leptospiruria and thrombocytopenia Bacterin Injectable vaccine Made in the USANobivac is a registered trademark of Intervet Inc., d/b/a Merck Animal Health, a subsidiary of Merck & Co. Inc.